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Previously, BPC 157 as an originally anti-ulcer peptide was implemented in inflammatory bowel disease trials [1015], and now multiple sclerosis [16], lethal dose (LD1) could be not achieved [1016]

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The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

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